Literature summary for 2.4.2.30 extracted from

Ost, G.S.; Wirth, C.; Bogdanovic, X.; Kao, W.C.; Schorch, B.; Aktories, P.J.K.; Papatheodorou, P.; Schwan, C.; Schlosser, A.; Jank, T.; Hunte, C.; Aktories, K.
Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins (2020), Sci. Adv., 6, eaaz2094 .

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Cloned(Commentary)

Cloned (Comment)	Organism
the ADP-ribosyltransferase domain of the protein is expressed in Saccharomyces cerevisiae strain MH272-3falpha and HeLa cells	Yersinia mollaretii

Protein Variants

Protein Variants	Comment	Organism
E160A	inactive	Yersinia mollaretii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-Rab5	Yersinia mollaretii	the enzyme ADP-ribosylates Rab5 at Gln79	nicotinamide + (ADP-D-ribosyl)n+1-Rab5 + H+	-	?
NAD+ + Rab31	Yersinia mollaretii	the enzyme ADP-ribosylates Rab31 at Gln64	nicotinamide + (ADP-D-ribosyl)-Rab31 + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Yersinia mollaretii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-Rab5	the enzyme ADP-ribosylates Rab5 at Gln79	Yersinia mollaretii	nicotinamide + (ADP-D-ribosyl)n+1-Rab5 + H+	-	?
NAD+ + Rab31	the enzyme ADP-ribosylates Rab31 at Gln64	Yersinia mollaretii	nicotinamide + (ADP-D-ribosyl)-Rab31 + H+	-	?

Subunits

Subunits	Comment	Organism
?	x * 70000, SDS-PAGE	Yersinia mollaretii

Synonyms

Synonyms	Comment	Organism
ADP-ribosyltransferase	-	Yersinia mollaretii
YART	-	Yersinia mollaretii

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Release 2023.1 (January 2023)